Research Opportunities at CSCRM

The following list represents potential intellectual property (IP) opportunities available at the Center for Stem Cell and Regenerative Medicine. IP is held by the partner institutions and may be explored further by contacting Michael Gilkey, Marketing and Operations Manager (meg14@case.edu, 216-368-2079).

Biology and Immunology:

• Induction and maintenance of tolerance to composite tissue allografts
• Notch-induced Natural Killer cells as cell therapy against malignancy
• Generation of an inflammatory wound healing delay
• Bone marrow targeting peptides
• Methods of regulation of nuclear factor of activated T-Cells-1 (NFAT1) and uses thereof
• Proteomic characterization of vascular endothelial cell-conditioned medium chemo-attractive to UCB cells
• Novel method for preparing large numbers of foxp3+ T regulatory cells for therapeutic suppression of auto immune diseases
• Methods for inducing donor recipient chimerism in an allograft transplant recipient
• High performance magnetic cell deposition system

Cardiovascular:

• Method and apparatus for fluidly isolating a portion of a body lumen wall from flow through the body lumen

Imaging:

• Double contrast technique for MRI-guided vascular interventions
• Steady state dark blood MRI
• A novel double-contrast technique to facilitate MRI-guided vascular interventions
• Synthesis of positron-labeled methoxyamine for in vivo detection and quantification of AP-sites

Neurology:

• Targeting the protein tyrosine phosphatase receptor as a molecular therapeutic for glioblastoma and prostate cancer
• Epineural sheath graft for nerve regeneration
• Control of spinal cord function by light activated channels and receptors

Oncology:

• A method for combining MGMT inhibitor and antimitotic agents to treat leukemia and solid tumor
• Identification of small molecular weight inhibitors of SHP-2 tyrosine phosphatase that is hyperactivated in childhood leukemia

Sensory:

• ELISA method for detection of patients with age-related macular degeneration (AMD)
• Timp 3 as a Therapeutic for AMD (knockout mouse)

Tissue Engineering:

• New photocrosslinked biodegradable hydrogel system
• Cartilage sheet culture chamber: A bioreactor for tissue engineering scaffold-free cartilage sheets

For a more in depth look at the research ongoing at CSCRM, please select from one of the choices to the left. To download a CSCRM Intellectual Property Factsheet please click here.