Center for Stem Cell and Regenerative Medicine Home CSCRM - Who We Are CSCRM - Events CSCRM - News & Publications CSCRM - Research CSCRM - Commercialization
CSCRM - Education CSCRM - Membership CSCRM - Career Opportunities CSCRM - Links CSCRM

Case Western Reserve University
Cleveland Clinic
University Hospitals Case Medical Center
The Ohio State UniversityAthersys Inc.

 


The Web CSCRM Site

Google

Kenneth R. Cooke, M.D.

Selected Peer-Reviewed Publications

  • Willi S, Cooke K, Goldwein J, August C, Olshan G, Moshang T. Growth in children after bone marrow transplantation for advanced neuroblastoma compared with growth after transplantation for leukemia or aplastic anemia. The Journal of Pediatrics. 1992;120:726-732.


  • D'Alessandro MP, Kozakewich HPW, Cooke KR, Taylor GA. Radiologic-pathologic Conference of Children's Hospital Boston:  New pulmonary nodules in a child undergoing treatment for a solid malignancy. Pediatric Radiology. 1996;26:19-21.


  • Krenger W, Cooke KR, Crawford JM, Sonis ST, Simmons R, Pan L, Delmonte J Jr., Karandikar M, Ferrara JLM. Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host disease. Transplantation. 1996;62:1278-1285.


  • Pan L, Bressler S, Cooke KR, Krenger W, Karandikar M, Ferrara JLM. Long-term engraftment, graft-versus-host disease and immunologic reconstitution after experimental transplantation of allogeneic peripheral blood cells from G-CSF treated donors. Biology of Blood and Bone Marrow Transplantation. 1996;2:126-133.


  • Cooke KR, Kobzik L, Martin TR, Brewer J, Delmonte J Jr, Crawford JM, Ferrara JLM. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: The roles of minor H antigens and endotoxin. Blood. 1996;88:3230-3239.


  • Cooke KR, Nishinakamura R, Martin TR, Kobzik L, Brewer J, Whitsett JA, Bungard D, Murray R, Ferrara JLM. Persistence of pulmonary pathology and abnormal lung function in IL-3/GM-CSF/IL-5 bc receptor deficient mice despite correction of alveolar proteinosis after BMT. Bone Marrow Transplantation. 1997;20:657-662.  * Reviewed in (1998) Progress in Growth Factors, 4, 43.


  • Hill GR, Crawford JM, Cooke KR, Brinson YS, Pan L, Ferrara JLM. Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines. Blood. 1997;90:3204-3213.


  • Hill GR, Cooke KR, Teshima T, Crawford JM, Keith Jr JC, Brinson YS, Bungard D, Ferrara JLM. Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation. The Journal of Clinical Investigation. 1998;102:115-123.


  • Cooke KR, Krenger W, Hill G, Martin TR, Kobzik L, Brewer J, Simmons R, Crawford JM, van den Brink M, Ferrara JLM. Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplant. Blood. 1998;92:2571-2580.


  • Cooke KR, Hill GR, Crawford JM, Bungard D, Brinson YS, Delmonte Jr J, Ferrara JLM. Tumor necrosis factor-alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease. The Journal of Clinical Investigation. 1998;102:1882-1891.


  • Hill GR, Cooke KR, Brinson YS, Bungard D, Ferrara JLM. Pretransplant chemotherapy reduces inflammatory cytokine production and acute graft-versus-host disease after allogeneic bone marrow transplantation. Transplantation. 1999;67:1478-1480.


  • Pan L, Teshima T, Hill GR, Bungard D, Brinson YS, Reddy VS, Cooke KR, Ferrara JLM. Granuloyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft-versus-leukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease. Blood. 1999;93:4071-4078.


  • Krijanovski OI, Hill GR, Cooke KR, Teshima T, Crawford JM, Brinson YS, Ferrara JLM. Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease. Blood. 1999;94:825-831.
  • Teshima T, Hill GR, Pan L, Brinson YS, van den Brink MRM, Cooke KR, Ferrara JLM. Interleukin-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation. The Journal of Clinical Investigation. 1999;104:317-325.


  • Hill GR, Teshima T, Gerbitz A, Pan L, Cooke KR, Brinson YS, Crawford JM, Ferrara JLM. Differential roles of Interleukin-1 and tumor necrosis factor-alpha on graft-versus-host disease and graft-versus-leukemia. The Journal of Clinical Investigation. 1999;104:459-467.


  • Hill GR, Teshima T, Rebel VI, Krijanovski OI, Cooke KR, Brinson YS, Ferrara JLM. The p55 tumor necrosis factor-alpha receptor plays a critical role in T cell alloreactivity. The Journal of Immunology. 2000;164:656-663.


  • Cooke KR, Hill GR, Gerbitz A, Kobzik L, Martin TR, Crawford JM, Brewer J, Ferrara JLM. Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation. Transplantation. 2000;70:272-279.


  • Cooke KR, Hill GR, Gerbitz A, Kobzik L, Martin TR, Crawford JM, Brewer JP, Ferrara JLM. Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: Potential role for a gut-lung axis of inflammation. The Journal of Immunology. 2000;165:6612-6619.


  • Cooke KR, Gerbitz A, Crawford JM, Teshima T, Hill GR, Tesolin A, Rossignol DP, Ferrara JLM. Lipopolysaccharide antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation. The Journal of Clinical Investigation. 2001;107:1581-1589.


  • Teshima T, Reddy P, Lowler KP, KuKuruga MA, Liu C, Cooke KR, Ferrara JLM. Flt3 ligand therapy for recipients of allogeneic bone marrow transplants expands host CD8 alpha(+) dendritic cells and reduces experimental acute graft-versus-host disease. Blood. 2002;99:1825-1832.


  • Teshima T, Ordemann R, Reddy P, Gagin S, Liu C, Cooke KR, Ferrara JLM. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nature Medicine. 2002;8(6):575-581.


  • Yanik G, Hellerstedt B, Custer J, Hutchinson R, Kwon D, Ferrara JLM, Uberti J, Cooke KR.  Etanercept (Enbrel) administration for idiopathic pneumonia syndrome after hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation. 2002;8:395-400.


  • Reddy P, Teshima T, Hildebrandt G, Duffner U, Maeda Y, Cooke KR, Ferrara JLM. Interleukin-18 preserves a perforin-dependent graft-versus-leukemia effect after allogeneic bone marrow transplantation. Blood. 2002;100:3429-3431.


  • Cooke KR, Olkiewicz K, Erickson N, Ferrara JLM. The role of endotoxin and the innate immune response in the pathophysiology of acute graft-versus-host disease. The Journal of Endotoxin Research. 2002;8:441-448.


  • Reddy P, Teshima T, Hildebrandt G, Williams D, Liu C, Cooke KR, Ferrara JLM. Pretreatment of donors with Interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects. Blood. 2003;101:2877-2885.


  • Teshima T, Reddy P, Liu C, Williams D, Cooke KR, Ferrara JLM. Impaired thymic negative selection causes autoimmune graft-versus-host disease. Plenary Paper. Blood. 2003;102:429-435.


  • Clouthier SG, Cooke KR, Teshima T, Lowler KP, Liu C, Connolly K, Ferrara JLM. Repifermin (keratinocyte growth factor-2) reduces the severity of graft-versus-host disease while preserving a graft-versus-leukemia effect. Biology of Blood and Marrow Transplantation. 2003;9:592-603.


  • Duffner U, Lu B, Hildebrandt G, Teshima T, Williams DL, Reddy P, Ordemann R, Clouthier SG, Lowler K, Liu C, Gerard C, Cooke KR, Ferrara JLM. Role of CXCR3-induced donor T-cell migration in acute graft-versus-host disease. Experimental Hematology. 2003;31(10):897-902.


  • Ojielo CI, Cooke KR, Mancuso P, Standiford TJ, Olkiewicz KM, Clothier SG, Corrion LA, Ballinger MN, Paine R III, Toews GB, Moore BB. Defective phagocytosis and clearance of Pseudomonas aeruginosa in the lung following bone marrow transplantation. The Journal of Immunology. 2003;171:4416-24.


  • Cooke KR, Ferrara JLM. “A Protective Gene of Graft-versus-Host Disease.” The New England Journal of Medicine. 2003; 349:2183-2184.


  • Hildebrandt GC, Duffner UA, Olkiewicz KM, Corrion LA, Willmarth NE, Williams DL, Clouthier SG, Hogaboam CM, Reddy PR, Moore BB, Kuziel WA, Liu C, Yanik G, Cooke KR. A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood. 2004;103:2417-2426.


  • Duffner U, Maeda Y, Cooke KR, Reddy P, Ordemann R, Liu C, Ferrara JLM, Teshima T. Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease. The Journal of Immunology. 2004;172:7393-7398.


  • Gerbitz A, Ewing P, Wilke A, Schubert T, Eissner G, Dietl B, Andreesen R, Cooke KR, Holler E. Induction of heme oxygenase-1 before conditioning results in improved survival and reduced graft-versus-host disease after experimental allogeneic bone marrow transplantation. Biology of Blood and Marrow Transplantation. 2004;10:461-472.


  • Hildebrandt GC, Olkiewicz KM, Corrion LA, Chang Y, Clouthier S, Liu C, Cooke KR. Donor-derived tumor necrosis factor-alpha regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood. 2004;104:586-593.


  • Hildebrandt GC, Corrion LA, Olkiewicz KM, Lu B, Lowler K, Duffner U, Moore BB, Kuziel WA, Liu C, Cooke KR. Blockade of CXCR3 receptor: Ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. The Journal of Immunology. 2004;173:2050-2059.


  • Hofmeister CC, Quinn A, Cooke KR, Stiff P, Nickoloff B, Ferrara JLM. “Graft-versus-host disease of the skin: Life and death on the epidermal edge.” Biology of Blood and Marrow Transplantation. 2004; 6:366-372.


  • Gerbitz A, Nickoloff B, Olkiewicz KM, Willmarth NE, Corrion LA, Hildebrandt GC, Kobzik L, Eissner G, Holler E, Ferrara JLM, Cooke KR. A role for tumor necrosis factor-alpha mediated endothelial apoptosis in the development of experimental idiopathic pneumonia syndrome. Transplantation. 2004;78:494-502.


  • Choi SW, Boxer LA, Pulsipher MA, Roulston D, Hutchinson RJ, Yanik GA, Cooke KR, Ferrara JL, Levine JE. Stem cell transplantation in patients with severe congenital neutropenia with evidence of leukemic transformation. Bone Marrow Transplantation. 2005;35:473-7.


  • Gerbitz A, Ewing P, Olkiewicz K, Willmarth NE, Williams D, Hildebrandt G, Wilke A, Liu C, Eissner G, Andreesen R, Holler E, Guo R, Ward PA, Cooke KR. A role for CD54 (intercellular adhesion molecule-1) in leukocyte recruitment to the lung during the development of experimental idiopathic pneumonia syndrome. Transplantation. 2005;79:536-42.


  • Moore BB, Kolodsick JE, Thannickal VJ, Cooke KR, Moore TA, Hogaboam C, Wilke CA, Toews GB. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. American Journal of Pathology 2005;166:675-84.


  • Hildebrandt GC, Olkiewicz KM, Choi S, Corrion LA, Serody JS, Clouthier S, Liu C, Cooke KR. Donor T cell production of RANTES significantly contributes to the development of experimental idiopathic pneumonia syndrome after allogeneic stem cell transplantation. (Plenary Paper) Blood, 2005; 105:2249-2257.


  • Uberti JP, Ayash L, Ratanatharathorn V, Silver S, Reynolds C, Becker M, Reddy P, Cooke KR, Yanik G, Whitfield J, Jones D, Hutchinson R, Braun T, Ferrara JLM, and Levine JE. Pilot trial on the use of etanercept and methylprednisolone as primary treatment for acute graft-versus-host disease. Biology of Blood and Marrow Transplantation, 2005; 11:680-687.


  • Choi SW, Islam S, Greenson JK, Levine J, Hutchinson R, Yanik G, Teitelbaum D, Ferrara JLM, and Cooke KR. The use of laparoscopic liver biopsies in pediatric patients with hepatic dysfunction following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation, 2005;36, 891-896.


  • Schultz KR, Miklos DB, Fowler D, Cooke KR, Shizuru J, Zorn E, Holler E, Ferrara J, Shulman H, Lee SJ, Martin P, Filipovich AH, Flowers ME, Weisdorf D, Couriel D, Lachenbruch PA, Mittleman B, Vogelsang GB, Pavletic SZ. Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report. Biology of Blood and Marrow Transplantation, 2006 Feb;12(2):126-37.


  • Ballinger MN, Aronoff DM, McMillan TR, Cooke KR, Olkiewicz K, Toews GB, Peters-Golden M, and Moore BB. Critical Role of Prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation, Journal of Immunology, 2006; 177:5499-5508


  • Ewing P, Miklos S, Olkiewicz KM, Müller, G, Andreesen R, Holler E, Cooke KR, and Hildebrandt GC. Donor CD4+ T cells are critical producers of tumor necrosis factor alpha during the early pro-inflammatory events of graft versus host disease. Experimental Hematology. 2007; 35:155-63.


  • Yoshihara S, Yanik G, Cooke KR, and Mineishi S. Bronchiolitis obliterans syndrome (BOS), bronchiolitis obliterans organizing pneumonia (BOOP) and other late onset non-infectious pulmonary complications following allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation 2007;13:749-59.


  • Hildebrandt GC, Choi SW, Olkiewicz KM, Moore BB, Mc Kenzie AN, and Cooke KR. The absence of donor-derived IL-13 exacerbates the severity of acute graft-versus-host disease following allogeneic bone marrow transplantation. Pediatric Blood and Cancer 2007 [Epub ahead of print]


  • Chao MM, Levine JE, Ferrara JL, Cooling L, Cooke KR, Hutchinson RJ, Yanik GA. Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with Campath-1H. Pediatric Blood and Cancer 2007 Apr 6; [Epub ahead of print]


  • Choi SW, Hildebrandt GC, Olkiewicz KM, Chaudhary MN, Silva IA, Fisher JM, Liu C, Chensue SW, and Cooke KR. CCR1:CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Blood2007; 110: 3447-3455


  • Cooke KR, Janin A and Ho V. The contribution of endothelial activation and injury to end organ toxicity following allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation. 2008;14:23-32


  • Hildebrandt GC, Olkiewicz KM, Corrion LA, Choi S, Clouthier SG, Liu C, and Cooke KR. A role for TNF receptor type II in leukocyte trafficking to the lung during experimental idiopathic pneumonia syndrome after allogeneic stem cell transplantation. Biology of Blood and Marrow Transplantion. 2008;14:385-96


  • Choi SW, Kitko CL, Braun T, Paczesny S, Yanik G, Mineishi S, Krijanovski O, Jones D, Whitfield J, Cooke KR, Hutchinson RJ, Ferrara JLM, and  Levine JE. Change in plasma Tumor Necrosis Factor Receptor 1 levels in the first week post-myeloablative allogeneic transplant correlates with severity and incidence of GVHD and survival. Blood. In Press


  • Yanik GA, Ho V, Levine JL, White E, Braun T, Antin J, Ferrara JLM and Cooke KR. Soluble tumor necrosis factor receptor: The impact of soluble tumor necrosis factor receptor: etanercept on the treatment of idiopathic pneumonia syndrome following allogeneic stem cell transplantation. Blood, In press.

    Book Chapters

  1. Ferrara JLM, Krenger W, Cooke KR, Pan L, Blazar BR, Crawford JM, Korngold R, Townsend RM, Levy RB, Baker M, Sykes M, Dey B, Yang YG, Chao N, Deeg HJ, Petersdorf E, Ringden O, Holler E, Heslop H, Niederwieser D, Murphy, G. “Recent advances and future directions.” Graft vs. Host Disease, 2nd Edition. Burakoff, SJ, Deeg, HJ, and Ferrara, JLM. (Eds.) New York: Marcel Dekker Inc., 1996: 775-810.


  2. Cooke, KR. “Mechanisms of Inflammation in GVHD Target Organs.” European Group for Blood and Marrow Transplantation (EBMT) Educational Book, 2001: 84-89.


  3. Cooke KR, Holler E. “Mechanisms of graft-versus-host disease and the graft-versus leukemia effect after allogeneic bone marrow transplantation.” European School of Hematology, EuroConference of Animal Models of Human Disease Educational Book, 2003.


  4. Cooke KR. “Graft-versus-host reactions after allogeneic hematopoietic stem cell transplantation.” 32nd Critical Care Congress, Current Concepts in Pediatric Critical Care, 2003: 65-81.


  5. Cooke KR. “The pathophysiology of lung injury after hematopoietic stem cell transplantation.” Stem Cell Transplantation for Hematologic Disorders, 1st Edition. Soiffer, RJ, ed. Totowa, NJ: Humana Press, 2004: 271-295.


  6. Ferrara JLM, Cooke KR, Teshima T. “The Pathophysiology of Graft-vs.-Host Disease.” Graft-vs.-Host Disease, 3rd Edition. Ferrara, Cooke, Deeg, eds. New York: Marcel Dekker, Inc., 2005: 1-34.


  7. Cooke KR, Serody JS, Welniak LA, Murphy WJ. “Chemokines and Graft-versus-Host Disease.” Graft-vs.-Host Disease, 3rd Edition. Ferrara, Cooke, Deeg, eds. New York: Marcel Dekker, Inc., 2005: 125-153.


  8. Cooke KR, Ferrara JLM. “The Pathophysiology of Lung Injury after Hematopoietic Stem Cell Transplantation.” Graft-vs.-Host Disease, 3rd Edition. Ferrara, Cooke, Deeg, eds. New York: Marcel Dekker, Inc., 2005: 329-367.


  9. Reddy P, Cooke KR, Ferrara JLM, Deeg HJ. “Recent advances and future directions.” Graft-vs.-Host Disease, 3rd Edition. Ferrara, Cooke, Deeg, eds. New York: Marcel Dekker, Inc., 2005: 609-630.

Grant Support:

Current
1. R01 Hl072258 (PI: Cooke)                                                    7/01/03 to 6/30/09
National Heart Lung and Blood Institute
Mechanisms of Leukocyte Recruitment during IPS after Allogeneic Stem Cell Transplant. $1,125,000 total costs Goals: To study the role of chemokine receptor: ligand interactions in leukocyte recruitment to the lung during the development of idiopathic pneumonia syndrome. Overlap: None

2. Leukemia and Lymphoma Society (PI: Cooke)                      7/01/05 to 6/30/10
Scholar in Clinical Research Award
Novel Strategies for the Diagnosis and Treatment of Acute Lung Injury after SCT. $550,000 total costs Overlap: None

3. Burroughs Wellcome Fund (PI: Cooke)                                 7/01/05 to 6/30/10
Clinical Scientist Award in Translational Research
Acute Lung Injury after SCT: Laboratory Insights to Novel Strategies for Diagnosis and Treatment $750,000 total costs Overlap: None

4. Hope Street Kids (PI Cooke)                                                05-01-07-04-30-09
Mechanisms of leukocyte recruitment to the lung during idiopathic pneumonia syndrome following allogeneic bone marrow transplantation
Major goal of this research project is to determine the role of selectin receptor:ligand interactions in the development of IPS following allogeneic BMT.

Return to Profile