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Case Western Reserve University
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Cheng-Kui Qu, Ph.D.

Selected Peer-Reviewed Publications

  1. Qu, C. K., Z. Q. Shi, R. Shen, F. Y. Tsai, S. H. Orkin, and G. S. Feng. 1997. A deletion mutation in SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Molecular and Cellular Biology. 17:5499-5507
  2. Qu, C. K., and G. S. Feng. 1998. Shp-2 has a positive regulatory role in ES cell differentiation and proliferation. Oncogene. 17:433-440
  3. Lu, X., C. K. Qu, Z. Q. Shi, and G. S. Feng. 1998. Down regulation of platelet-derived growth factor receptor-b in Shp-2 mutant cell lines. Oncogene. 17:441-448
  4. Yu, D. H., C. K. Qu, O. Henegariu, X. Lu, and G. S. Feng. 1998. Protein tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. The Journal of Biological Chemistry. 273:21125-21131
  5. Qu, C. K., W. M. Yu, B. Azzarelli, S. Cooper, H. E. Broxmeyer, and G. S. Feng. 1998. Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Molecular and Cellular Biology. 18:6075-6082
  6. Qu, C. K., W. M. Yu, B. Azzarelli, and G. S. Feng. 1999. Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals. Proceedings of the National Academy of Sciences of the United States of America. 96:8528-8533
  7. Kim, C. H., C. K. Qu, G. Hangoc, S. Cooper, G. S. Feng, and H. E. Broxmeyer. 1999. Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses. The Journal of Experimental Medicine. 190:681-690
  8. Qu, C. K. 2000. The SHP-2 tyrosine phosphatase: Signaling mechanisms and biological functions. Cell Research. 10:279-288
  9. Qu, C. K., S. Nguyen, J. Z. Chen, and G. S. Feng. 2001. Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development. Blood. 97:911-914
  10. Yu, W. M., T. S. Hawley, R. G. Hawley, and C. K. Qu. 2002. Role of the docking protein Gab2 in b1 integrin signaling pathway-mediated hematopoietic cell adhesion and migration. Blood. 99:2351-2359
  11. Qu, C. K. 2002. Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response. Biochemia et Biophysics Acta. 1592:297-301
  12. Yu, W. M., T. S. Hawley, R. G. Hawley, and C. K. Qu. 2002. Immortalization of yolk sac-derived precursor cells. Blood. 100:3828-3831
  13. Shen, R., Y. B. Ouyang, C. K. Qu, A. Alonso, L. Sperzel, T. Mustelin, M. H. Kaplan, and G. S. Feng. 2002. Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Molecular and Cellular Biology. 22:3230-3236
  14. Hanson, E. M., H. Dickensheets, C. K. Qu, R. Donnelly, and A. D. Keegan. 2003. Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome. The Journal of Biological Chemistry. 278:3903-3911
  15. Yuan, L., W. M. Yu, Z. Yuan, C. C. Haudenschild, and C. K. Qu. 2003. Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response. The Journal of Biological Chemistry. 278:15208-15216
  16. Yu, W. M., T. S. Hawley, R. G. Hawley, and C. K. Qu. 2003. Catalytic-dependent and –independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling. Oncogene. 22:5995-6004
  17. Yuan, L., W. M. Yu, and C. K. Qu. 2003. DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized murine embryonic fibroblast cells requires SHP-2 tyrosine phosphatase. The Journal of Biological Chemistry. 278:42812-42820
  18. Zamorano, J., M. D. Rivas, A. Garcia-Trinidad, C. K. Qu, and A. D. Keegan. 2003. Phosphatidylcholine-specific phospholipase C activity is necessary for the activation of STAT6. The Journal of Immunology. 171:4203-4209
  19. Yao, P., Y. Zhan, W. Xu, C. Li, P. Yue, C. Xu, D. Hu, C. K. Qu, and X. Yang. 2004. Hepatocyte growth factor-induced proliferation of hepatic stem-like cells depends on activation of NF-kB. Journal of Hepatology. 40:391-398
  20. Chen, J., W. M. Yu, K. D. Bunting, and C. K. Qu. 2004. A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival. Oncogene. 23:3659-3669
  21. Bunting, K. D., W. M. Yu, H. L. Bradley, N. Haviernikova, A. Kelly-Welch, A. D. Keegan, C. K. Qu. 2004. Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression. Journal of Leukocyte Biology. 76:484-490
  22. Yu, W. M., S. Y. Wang, A. D. Keegan, M. S. Williams, and C. K. Qu. 2005. Abnormal T helper 1 cell differentiation and IFN-g production in T lymphocytes from motheaten viable mice mutant for SHP-1 tyrosine phosphatase. The Journal of Immunology. 174:1013-1019
  23. Kwon, J., C. K. Qu, J. S. Maeng, R. Falahati, C. Lee, and M. S. Williams. 2005. Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-ADAP. The EMBO Journal. 24:2331-2341
  24. Yuan, L., W. M. Yu, M. Xu, and C. K. Qu. 2005. SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M checkpoint in catalytic-dependent and –independent manners, respectively. The Journal of Biological Chemistry. 280:42701-42706
  25. Seo, D. W., H. Li, C. K. Qu, J. Oh, Y. S. Kim, T. Diaz, B. Wei, J. W. Han, and W. G. Stetler-Stevenson. 2006. Shp-1 mediates the anti-proliferative activity of TIMP-2 in human microvascular endothelial cells. The Journal of Biological Chemistry. 281:3711-3721
  26. Yu, W. M., H. Daino, J. Chen, K. D. Bunting, and C. K. Qu. 2006. Effects of a leukemia associated gain-of-function mutation of SHP-2 phosphatase on IL-3 signaling. The Journal of Biological Chemistry. 281:5426-5434
  27. Duan, H. F., C. K. Qu, Q. W. Zhang, W. M. Yu, H. Wang, C. T. Wu, and, L. S. Wang. 2006. Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts. Cellular Signaling. 18: 2049-2055
  28. Chen, J., W. M. Yu, H. Daino, H. E. Broxmeyer, B. J. Druker, and C. K. Qu. 2007. SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl. Blood. 109:778-785
  29. Amin, A. R. M. R., V. S. Thakur, R. K. Paul, G. S. Feng, C. K. Qu, H. Mukhtar, and M. L. Agarwal. 2007. SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG. Proceedings of the National Academy of Sciences of the United States of America. 104:5419-5424
  30. Guvench, O., C. K. Qu, and A. D. MacKerell, Jr. 2007. Tyr66 acts as a conformational switch in the closed®open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft. BMC Structural Biology. 7:14
  31. Zhang, Y., E. Diaz-Flores, G. Li, Z. Wang, Z. Kang, E. Haviernikova, S. Rowe, C. K. Qu, W. Tse, K. M. Shannon, and K. D. Bunting. 2007. Abnormal hematopoiesis in Gab2 mutant mice. Blood. 110:116-124
  32. Soebiyanto, R. P., S. N. Sreenath, C. K. Qu, K. A. Loparo, and K. D. Bunting. 2007. Complex Systems Biology Approach to Understanding Coordination of JAK-STAT Signaling. BioSystems. 90:832-840
  33. Shen, J and C. K. Qu. 2008. In vitro hematopoietic differentiation of murine embryonic stem cells. Methods in Molecular Biology. 430:103-118
  34. Xu, D. and C. K. Qu. 2008. Protein tyrosine phosphatases in the JAK/STAT pathway. Frontiers in Bioscience. 13:4925.
  35. Yu, W. M., O. Guvench, A. D. MacKerell, Jr., C. K. Qu. 2008. Identification of small molecular weight inhibitors of SHP-2 tyrosine phosphatase via in silico screening combined with experimental assay. Journal of Medicinal Chemistry. 51:7396-7404
  36. Wang, S. Y., W. M. Yu, W. Zhang, K. R. McCrae, B. G. Neel, and C. K. Qu. 2009. Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase enhance cell migration and angiogenesis. The Journal of Biological Chemistry. 284:913-920
  37. Zheng, H., S. Alter, and C. K. Qu. 2009. SHP-2 tyrosine phosphatase in human diseases. International Journal of Clinical and Experimental Medicine. 2:17-25
  38. Shen, J., W. M. Yu, M. Brotto, J. A. Scherman, C. Guo, C. Stoddard, T. M. Nosek, H. H. Valdivia, and C. K. Qu. 2009. Deficiency of MIP phosphatase induces a muscle disorder by compromising Ca2+ homeostasis. Nature Cell Biology, 11:769-776
    Featured in the Press Release for Nature Cell Biology, May 24, 2009 (http://www.nature.com/ncb/press_release/ncb0509.html).

Ongoing Research Support:

  1. 1. R01 HL068212 (Qu) 07/01/02-12/16/2012 NHLBI, NIH “Protein tyrosine phosphatase and hematopoietic cell regulation”
  2. 2. R21 HL082670 (Qu) 07/16/07-07/15/2010 NHLBI, NIH “SHP-2 inhibitors as potential therapeutic agents for JMML and Noonan syndrome”
  3. 3. Sponsorship of the International Short-term Scientist Exchange Program, NCI/NIH Qu, CK (P.I.) 06/2008-05/2009
  4. 4. Case Comprehensive Cancer Center cancer biology-structural biology pilot grant (Qu). 05/2007-04/2009 “Targeting SHP-2 tyrosine phosphatase for the treatment of childhood leukemias”
  5. 5. JMML foundation (Qu) “Targeting SHP-2 (PTPN11) phosphatase for the treatment of JMML” Approved for funding

 

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